3:45–4:45 pm
GCIS W301/303 929 E. 57th St
Learning the physics of collective cell migration
The majority of cells in our body do not move around—but when they do, it is for an important reason: single and collectively migrating cells shape us during development, they protect us during immune response but can also harm us during cancer progression. Yet, the underlying dynamics of how cells move and interact with each other and their environment remains unclear. I will discuss how data-driven theoretical approaches can be used to learn the dynamical laws underlying cell movement, morphology and interactions of cells in controlled artificial environments. By inferring a stochastic equation of motion directly from experimental data, we show that cells exhibit intricate non-linear deterministic dynamics that adapt to the geometry of confinement. We extend this approach to interacting systems, by tracking how trajectories of colliding pairs of cells scatter. This allows us to develop and constrain a phenomenological theory of contact-interactions between cells. Finally, I will discuss how our approach can be generalized to identify the interactions rules underlying the many-body stochastic dynamics that controls collective migration in multicellular systems.
Host: Prof. Suri Vaikuntanathan, Dept. of Chemistry (svaikunt@uchicago.edu)
About the JFI Colloquium: The James Franck Institute Colloquium is a monthly event inviting distinguished scholars from research institutions around the globe to share creative, groundbreaking research at the intersection of chemistry, physics, and materials science. As an interdisciplinary institution, the JFI welcomes researchers and students from a wide variety of scientific disciplines to attend and partake in lively discussion. Colloquium speakers are nominated by JFI faculty and selected annually by the colloquium committee. Find the full calendar on the JFI website.